Monoglyceride of acetoacetate and derivatives for the...

A - Human Necessities – 61 – K

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A61K 31/19 (2006.01)

Patent

CA 2729622

This invention relates to methods of using the monoglyceride of acetoacetate and metabolic precursors for the treatment, prevention, inhibition or alleviation of neurological diseases associated with neuronal hypometabolism, such as Alzheimer's disease, Parkinson's disease, Friedreich's Ataxia (FRDA), GLUT 1- deficient Epilepsy, Leprechaunism and Rabson-Mendenhall Syndrome, Coronary Arterial Bypass Graft (CABG) dementia, anesthesia induced memory loss, age associated memory impairment (AAMI), Traumatic Brain Injury (TBI), Huntington's disease and many others.

L'invention concerne des procédés d'utilisation du monoglycéride d'acétoacétate et de précurseurs métaboliques pour le traitement, la prévention, l'inhibition ou l'atténuation de troubles neurologiques associés à un hypométabolisme neuronal, comme la maladie d'Alzheimer, la maladie de Parkinson, l'ataxie de Friedreich (FRDA), une épilepsie à déficience de GLUT1, le lepréchaunisme et le syndrome de Rabson-Mendenhall, une démence aorto-coronarienne (CABG), une perte de mémoire suite à une anesthésie, des troubles de la mémoire de la personne âgée (AAMI), une lésion cérébrale traumatique (TBI), la maladie de Huntington et de nombreux autres.

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