Monolithic tablet for controlled drug release

Details Monolithic tablet for controlled drug release Monolithic tablet for controlled drug release

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/138 (2006.01) A61K 31/277 (2006.01) A61K 31/554 (2006.01) A61K 47/02 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2323102

A swellable hydrophilic matrix tablet that delivers drugs in a controlled manner over a long period of time and is easy to manufacture. More specifically, the drug is disposed in a matrix composed of HPMC or polyethylene oxide, in the presence of a salt, which may be a combination of salts. Suitable salts include sodium bicarbonate, sodium chloride, potassium bicarbonate, calcium chloride, sodium bisulfate, sodium sulfite, and magnesium sulfate. Outward diffusion of the drug is controlled by an inwardly progressing hardening reaction between the salt and the dissolution medium, possibly also involving the drug itself.

L'invention concerne un comprimé à matrice gonflable hydrophile qui assure l'apport contrôlé en médicament sur une longue période et qui est facile à fabriquer. Plus précisément, le médicament est disposé dans une matrice constituée de méthylcellulose hydroxypropylée ou d'oxyde de polyéthylène, en présence d'un sel ou d'une combinaison de sels. Les sels qui conviennent à cette fin comprennent le bicarbonate de sodium, le chlorure de sodium, le bicarbonate de potassium, le chlorure de calcium, le bisulfate de sodium, le sulfite de sodium et le sulfate de magnésium. La diffusion du médicament vers l'extérieur est contrôlée par une réaction de durcissement évoluant vers l'intérieur entre le sel et le milieu de dissolution et concerne éventuellement le médicament proprement dit.

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