C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/02 (2006.01) A61K 31/47 (2006.01) C07D 217/04 (2006.01) C07D 217/24 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2313487
The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers, wherein either or both of said monomer(s) is (are) monomeric compound(s) of the present invention. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
L'invention concerne de nouveaux dérivés monomères d'un alcaloïde de la naphtylisoquinoline possédant une liaison C8'-C7, la dioncophylline D; des dérivés d'un alcaloïde monomères de l'arylisoquinoline substitué en C4; et des alcaloïdes dimères de l'arylisoquinoline constitués de premiers et de seconds monomères d'arylisoquinoline couplés, l'un ou les deux monomères étant les composés monomères de la présente invention. Les composés monomères et dimères de la présente invention ont des propriétés utiles sur le plan médical, telles que des propriétés antimicrobiennes, notamment anti-paludéennes, et antivirales. Les composés monomères sont également utiles comme éléments constitutifs ou comme intermédiaires pour la synthèse de nouveaux alcaloïdes dimères de l'arylisoquinoline. Les composés monomères et dimères peuvent être obtenus sous leur forme sensiblement pure par synthèse totale, synthèse partielle ou dérivatisation à partir de composés synthétiques ou naturels connus, ainsi que par isolement et purification à partir de plantes appartenant aux familles des Dioncophyllaceae et des Ancistrocladaceae.
Boyd Michael R.
Bringmann Gerhard
Wenzel Matthias
Depar Tment Of Health And Human Services The Government Of The United States Represented By The Secretary
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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