Monomeric insulin

Details Monomeric insulin Monomeric insulin

C - Chemistry, Metallurgy

12

N

C12N 15/17 (2006.01) A61K 38/28 (2006.01) C07K 14/62 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2492728

This invention provides a novel monomeric insulin (B27K-DTrI, B27K- destripeptide-Insulin), its composition and the method of preparation therefore. Highly pure B27K-DTrI-Insulin is monomeric (non-associative at high concentration and physiological pH) with in-vivo bioactivity being 80% of that of native insulin. B27K-DTrI-Insulin can be produced by enzyme cleavage of a monomeric insulin precursor secreted by yeast instead of by the less efficient enzyme transpeptidation as known in the prior art. The new method increases the total yield and is favorable for industrial production.

L'invention se rapporte à une nouvelle insuline monomère (B<sb>27</sb>K-DTrI, B<sb>27</sb>K-destripeptide-Insuline), à sa composition et à un procédé permettant sa préparation. La B<sb>27</sb>K-DTrI-Insuline de grande pureté est monomère (non associative à une concentration élevée et à pH physiologique) avec une bioactivité in-vivo égale à 80 % de celle de l'insuline native. La B<sb>27</sb>K-DTrI-Insuline peut être produite par clivage enzymatique d'un précurseur d'insuline monomère sécrété par de la levure plutôt que par la transpeptidation enzymatique moins efficace pratiquée à ce jour. Ce nouveau procédé permet d'accroître le rendement total et il est avantageux pour une production industrielle.

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