C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2381219
The present invention is concerned with proteins selected from the members of the TGF-.beta. superfamily, which are monomeric due to substitution or deletion of a cysteine which is responsible for dimer formation. The invention is also concerned with nucleic acids, encoding such monomeric proteins, vectors or host cells containing the nucleic acids as well as with pharmaceutical compositions comprising the proteins or nucleic acids encoding the proteins. The pharmaceutical compositions can be applied advantageously for all indications for which the respective dimeric proteins are useful.
La présente invention concerne des protéines sélectionnées parmi les membres de la superfamille des TGF-béta. Ces protéines sont des monomères du fait de la substitution ou de l'effacement d'une cystéine qui est responsable de la formation de dimères. L'invention traite aussi d'acides nucléiques codant ces protéines monomères, des vecteurs ou des cellules hôtes contenant ces acides nucléiques ainsi que des compositions pharmaceutiques comprenant les protéines ou les acides nucléiques codant ces protéines. Ces compositions pharmaceutiques peuvent être appliquées, de manière avantageuse, pour toutes les indications pour lesquelles les protéines dimères correspondantes sont utiles.
Bechtold Rolf
Hotten Gertrud
Pohl Jens
Hygene Ag
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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