Monomeric recombinant mhc molecules useful for manipulation...

Details Monomeric recombinant mhc molecules useful for manipulation... Monomeric recombinant mhc molecules useful for manipulation...

A - Human Necessities

61

K

A61K 38/16 (2006.01)

Patent

CA 2537759

The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have redesigned surface features that preclude or reduce aggregation, wherein the modified molecules retain the ability to bind Ag-peptides, target antigen-specific T cells, inhibit T cell proliferation in an Ag-specific manner and have utility to treat, inter alia, autoimmune disease and other conditions mediated by antigen-specific T cells in vivo.

L'invention porte dans des exécutions particulières sur des ligands (RTLs) de récepteurs de lymphocytes T (TCR) de recombinaison modifiés comportant un composant MHC de classe I ou de classe II. Les RTLs modifiés présentent des caractéristiques de surface empêchant ou réduisant l'agrégation tout en conservant la capacité de se fixer à des peptides Ag, de cibler des lymphocytes T spécifiques d'antigènes, d'inhiber la prolifération des lymphocytes T d'une manière spécifique à l'Ag, tout en s'avérant utiles pour traiter notamment les maladies auto-immunes et d'autres états médiés in vivo par des lymphocytes T spécifiques d'antigènes..

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