C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) A61K 49/02 (1990.01)
Patent
CA 2077345
2077345 9113085 PCTABS00007 The invention relates to novel endothelial cell-leukocyte adhesion molecules designated ATHERO-ELAM. ATHERO-ELAM molecules are expressed on cultured endothelial cells stimulated with bacterial LPS and selectively mediate the binding of monocytes to the endothelial cells. Monoclonal antibodies specific for ATHERO-ELAM bind to vascular endothelial cells involved in early atherosclerotic lesions, but not to vascular endothelial cells from uninvolved arterial tissue. ATHERO-ELAM and antibodies directed to ATHERO-ELAM may be used in identifying early atherosclerotic lesions and in treating and preventing atherosclerosis.
Collins Tucker
Cybulsky Myron I.
Gimbrone Michael A. Jr.
Brigham And Womens's Hospital
Collins Tucker
Cybulsky Myron I.
Gimbrone Michael A. Jr.
Gowling Lafleur Henderson Llp
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