Mononucleotide analogues and intermediates therefor

Details Mononucleotide analogues and intermediates therefor Mononucleotide analogues and intermediates therefor

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07H 7/00 (2006.01) C07H 9/04 (2006.01) C07H 13/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2117014

ABSTRACT OF THE DISCLOSURE Mononucleotide Analogues and Intermediates Therefor A compound of formula Image I where R1 is hydrogen or a protecting group Q; R2 is hydrogen, a C1-C8 aliphatic radical, a C6-C15 aromatic radical, a C3-C8 cycloaliphatic radical, a C7-C13 araliphatic radical, an alkali metal ion or an ammonium ion; R3 and R4 are independently hydrogen, halogen or hydroxy; R5 is C6-C10 aryloxythiocarbonyloxy, the C6-C10 aryl group being unsubstituted or substituted, or R5a; R5a is hydrogen, fluorine, chlorine, hydroxy, -OR8, -OCOR8 or silyloxy substituted by three C1-C15 hydrocarbyl groups; R6 is hydrogen, a C1-C10 aliphatic radical, a C6-C15 aromatic radical, a C7-C16 araliphatic radical, -COR9, -SO2R9 or silyl substituted by three C1-C15 hydrocarbyl groups; R7 is a monovalent nucleoside base radical, hydroxyl, -OR8 or -OCOR8, and and R9 are independently a C1-C10 aliphatic radical, a C3-C8 cycloaliphatic radical, a C6-C15 aromatic radical or a C7-C16 araliphatic radical; or R5 and the indicated R6O-together denote an isopropylidenedioxy group or R5 and R7 together denote an isopropylidenedioxy group, provided that when R5 and R7 together denote isopropylidenedioxy, R1 R2, R3 R4 and R6 are not all hydrogen.

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