C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/36 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/18 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) G01N 33/536 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2222134
The invention provides monospecific antibodies which are specifically reactive with the .alpha.E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti- .alpha.E probes, including monospecific anti-.alpha.E antibodies which have been detectably labeled. In addition, the invention provides methods for using the monospecific antibodies for detection of the .alpha.E subunit and fragments thereof, as well as reagents and kits performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha.E antibodies.
Cette invention concerne des anticorps monospécifiques qui réagissent de manière spécifique à la sous-unité .alpha.¿E? de fibrinogène ou à un de ses fragments, mais à aucune autre partie de la molécule de fibrinogène. Cette invention concerne également des sondes anti-.alpha.¿E? comprenant des anticorps monospécifiques anti-.alpha.¿E? qui ont été marqués de manière détectable. En outre, cette invention concerne des procédés d'utilisation des anticorps monospécifiques afin de détecter la sous-unité .alpha.¿E? et ses fragments, ainsi que des réactifs et des nécessaires permettant de mettre en oeuvre ces procédés. Cette invention concerne également des procédés de diagnostic permettant d'établir des informations liées à l'athérogenèse et/ou à la thrombogenèse, ainsi que des informations liées à l'état ou à l'issue de la grossesse. Cette invention concerne enfin des lignées cellulaires continues qui produisent les anticorps monospécifiques anti-.alpha.¿E?.
Ahadi Mohamad Zaher
Cao Yan
Fu Yiping
Grieninger Gerd
Kudryk Bohdan J.
New York Blood Center Inc.
Piasetzki & Nenniger Llp
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