C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 16/12 (2006.01) C12N 1/36 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2253636
The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the OMP106 polypeptide and/or OMP106-derived polypeptides. Also disclosed are immunogenic, prophylactic or therapeutic compositions, including vaccines, comprising OMP106 polypeptide and/or OMP106- derived polypeptides. The invention additionally discloses methods of inducing immune responses to M. catarrhalis and M. catarrhalis OMP106 polypeptides and OMP106-derived polypeptides in animals.
L'invention concerne le polypeptide de la protéine-106 (OMP106) de la membrane externe de Moraxella catarrhalis, les polypeptides dérivés de cette protéine (polypeptides dérivés d'OMP106), les séquences de nucléotides codant pour ces polypeptides et les anticorps qui lient spécifiquement le polypeptide d'OMP106 et/ou les polypeptides dérivés d'OMP106. L'invention concerne également des compositions immunogènes, prophylactiques ou thérapeutiques, y compris les vaccins, qui contiennent le polypeptide d'OMP106 et/ou des polypeptides dérivés d'OMP106. En outre, l'invention concerne des méthodes permettant d'induire chez l'animal une réponse immunitaire à M. catarrhalis et aux polypeptides OMP106 et dérivés de M. catarrhalis.
Plosila Laura
Tucker Kenneth
Antex Biologics Inc.
Antex Biologics Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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