Morphinane derivatives

Details Morphinane derivatives Morphinane derivatives

C - Chemistry, Metallurgy

07

D

260/237.6

C07D 221/28 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1195324

ABSTRACT There are described novel acylmorphinan derivatives and their pharmaceutically acceptable acid addition salts as well as the use of these compounds as analgesic agents. These acylmorphinan derivatives can be characterized by the general formula Image wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl-lower alkyl, cyano-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl, R2 is (C2-7)-alkanoyl, arylcarbonyl, trifluoromethyl- carbonyl or the group RR'C(OH)-, R is (C1-6)-alkyl and R' is hydrogen or lower alkyl.

415102

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