Morphinone reductase for the preparation of hydromorphone...

Details Morphinone reductase for the preparation of hydromorphone... Morphinone reductase for the preparation of hydromorphone...

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) C12P 17/18 (2006.01) C12Q 1/32 (2006.01)

Patent

CA 2137548

A morphinone reductase enzyme having the characteristics: (1) with the NADH cofactor it reduces morphinone to hydromorphone; (2) with the same cofactor it also reduces codeinone and neopinone but has no significant enzymatic activity in the reverse direction; (3) it has a molecular weight of about 81,000, as determined by gel filtration; and (4) in phosphate buffer it exhibits maximal activity at pH about 8Ø

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