Morphogen analogs and methods for producing them

Details Morphogen analogs and methods for producing them Morphogen analogs and methods for producing them

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) C07K 1/00 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2244228

The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human osteogenic protein-1 (hOP-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human OP-1- like biological activity. The invention also provides a family of morphogen analogs produced by such methods.

La présente invention concerne des procédés et des compositions de conception assistée par ordinateur d'analogues morphogènes. La mise en ?uvre de l'invention est rendue possible par l'utilisation d'au moins une partie des coordonnées atomiques définissant la structure tridimensionnelle de la protéine ostéogène 1 (hOP-1) d'origine humaine comme point de départ de la conception d'analogues morphogènes. L'invention concerne en outre des procédés de production d'analogues morphogènes intéressantes et des procédés de test permettant de vérifier si les analogues résultants imitent ou agonisent l'activité biologique de type OP-1 humaine. L'invention concerne également une famille d'analogues morphogènes obtenus selon de tels procédés.

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