Morphogen-induced liver regeneration

Details Morphogen-induced liver regeneration Morphogen-induced liver regeneration

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 6/00 (2006.01) A61K 35/407 (2006.01) A61K 38/18 (2006.01) A61L 27/22 (2006.01) A61L 27/24 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61F 2/00 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2144514

Disclosed are therapeutic treatment methods, compositions and devices for maintaining liver function in a mammal, in- cluding means for regenerating lost or damaged hepatic tissue, means for enhancing viability and integration of hepatic tissue and organ transplants, and means for correcting liver function deficiencies, including means for enhancing diminished liver func- tion due to tissue injury or disease. The methods, compositions and devices on this invention all provide a therapeutically effec- tive morphogen concentration to the hepatic cells to be treated. Also disclosed are methods and compositions useful in a gene therapy or drug delivery protocol for correcting a protein deficiency in a mammal.

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