Morphogenic protein-specific cell surface receptors and uses...

Details Morphogenic protein-specific cell surface receptors and uses... Morphogenic protein-specific cell surface receptors and uses...

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2187902

Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.

L'invention porte (1) sur des séquences d'acides nucléiques, des séquences d'acides aminés, des homologies, des traits structuraux, et autres données caractérisant certains récepteurs morphogènes de surface cellulaire, et en particulier ceux fixant l'OP-1; (2) sur des méthodes de production de protéines réceptrices et de leurs fragments par recombinaison de l'ADN; (3) sur des méthodes d'identification de nouveaux récepteurs morphogènes de l'ADN codant pour eux; (4) sur des méthodes et compositions servant à identifier des composés capables de moduler les niveaux des récepteurs endogènes morphogènes; et (5) sur des méthodes et compositions d'identification d'analogues de fixation des récepteurs morphogènes servant à constituer des agonistes et antagonistes morphogènes à des fins thérapeutiques, diagnostiques et expérimentales.

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