Morpholin- and thiomorpholin-4-ylamides

Details Morpholin- and thiomorpholin-4-ylamides Morpholin- and thiomorpholin-4-ylamides

C - Chemistry, Metallurgy

07

K

C07K 5/027 (2006.01) A61K 38/06 (2006.01) C07K 1/06 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093109

4-19041/A Abstract Morpholin- and thiomorpholin-4-ylamides There are described compounds of formula I Image (I), wherein R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl- or naphthyl-lower alkoxy- carbonyl, heterocyclylcarbonyl wherein heterocyclyl contains 5 or 6 ring atoms, is saturated and is bonded to the carbonyl group via a ring nitrogen atom and, in addition to the bonding nitrogen atom, contains as ring member one or more further heteroatoms selected from unsubstituted or C1-C4alkyl-substituted NH, O, S, S=O and SO2, or is lower alkanoyl, phenyl- or naphthyl-lower alkanoyl or lower alkanesulfonyl, R3 is morpholino, thiomorpholino, S-oxothiomorpholino or S,S-dioxothiomorpholino, the heterocyclyl radical in heterocyclylcarbonyl R2 having the same definition as R3 or having a definition other than R3, and R4 is hydrogen, hydroxy, C1-C4alkoxy, cyano, trifluoromethyl or fluorine, and salts of those compounds where salt-forming groups are present. These compounds are inhibitors of HIV-protease and are used in the treatment of AIDS.

Affiliated with

Also associated with

Rating

Morpholin- and thiomorpholin-4-ylamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Morpholin- and thiomorpholin-4-ylamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morpholin- and thiomorpholin-4-ylamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1894899