C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/5386 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01) C07D 265/00 (2006.01) C07D 307/00 (2006.01) C07D 471/00 (2006.01) C07D 471/04 (2006.01) C07D 498/00 (2006.01) C07D 498/08 (2006.01)
Patent
CA 2452590
The invention relates to novel pyrazolopyridine derivatives of formula (I), wherein R1 represents (a) or (b) and n represents 1 or 2 and R2 represents H NH2. The invention also relates to salts, isomers and hydrates thereof as stimulators for soluble guanylate cyclase and to their use as agents in the treatment of cardiovascular diseases, hypertonicity, thrombo-embolic diseases and ischemia, sexual dysfunction or inflammations and for the treatment of diseases of the central nervous system.
La présente invention concerne de nouveaux dérivés de pyrazolopyridine de formule (I), dans laquelle R?1¿ représente (a) ou (b) et n est égal à 1 ou à 2 et R?2¿ représente H ou NH¿2?, ainsi que des sels, des isomères et des hydrates de ceux-ci, ces composés stimulant la guanylate-cyclase soluble. L'invention concerne par ailleurs l'utilisation de ces composés pour traiter des maladies cardio-vasculaires, l'hypertonie, des maladies thromboemboliques et des ischémies, une dysfonction sexuelle ou des inflammations, ainsi que des maladies du système nerveux central.
Alonso-Alija Cristina
Dembowsky Klaus
Feurer Achim
Flubacher Dietmar
Lang Dieter
Bayer Healthcare Ag
Fetherstonhaugh & Co.
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