Morpholine derivatives, preparation thereof and use thereof

Details Morpholine derivatives, preparation thereof and use thereof Morpholine derivatives, preparation thereof and use thereof

C - Chemistry, Metallurgy

07

D

167/215, 260/242

C07D 413/14 (2006.01) C07D 265/32 (2006.01) C07D 417/14 (2006.01) C07D 473/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 1249813

ABSTRACT OF THE DISCLOSURE MORPHOLINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF Morpholine derivatives of the formula: Image wherein R1 is a heterocyclic group selected from uracilyl, cytosinyl, hypoxanthinyl, adeninyl and thiazolyl, which may be substituted with halogen or carbamoyl, R2 is an N-containinq unsaturated heterocyclic group which may be substituted with oxo or lower alkyl, and R3 is a hydrogen atom or a phosphono group, and method therefor. The derivatives, and pharmaceutically acceptable salts thereof, have antitumor activity.

451881

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