Morpholino compounds

Details Morpholino compounds Morpholino compounds

C - Chemistry, Metallurgy

07

D

260/247.8

C07D 265/30 (2006.01) A61K 6/00 (2006.01)

Patent

CA 1154769

ABSTRACT Novel morpholino compounds having the general formula I Image wherein R1 is a straight or branched alkyl group containing 6 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group, the sum of the carbon atoms in the groups R1 and R2 being at least 10 and referably 10 to 20; and pharmaceutically acceptable salts thereof. Compositions for the treatment of the oral cavity and especially the tooth surfaces containing the novel compound or a salt thereof, preferably from 0.1 to 5 % by weight thereof. Use of the compounds to inhibit the formation of dental plaque or remove plaque already formed by application of the compound in an aqueous solution or a composition to the surfaces of the oral cavity, especially the surfaces of the teeth. Processes for the preparation of the compounds.

373524

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