C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/22 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) C07D 209/24 (2006.01)
Patent
CA 2373532
The compound, ((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4- yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
Cette invention concerne un composé ((3-(2-amino-1,2-dioxoéthyl)-2-éthyl-1-(phénylméthyl)-1H-indol-4-yl)oxy) acétique-morpholino-N-éthyl ester, ainsi que son utilisation comme composé indole à biodisponibilité élevée. Ce composé est capable d'inhiber la libération d'acides gras induite par sPLA¿2? et convient pour le traitement d'états pathologiques tels qu'un choc septique.
Beight Douglas Wade
Buben John Andrew
Morin John Michael Junior
Sall Daniel Jon
Sawyer Jason Scott
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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