Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors

Details Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors

A - Human Necessities

61

K

A61K 31/535 (2006.01) C07D 209/42 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2308443

The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2- methyl-1H-indol-4-yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

L'invention concerne le composé d'ester de morpholino-N-éthyle d'acide ((3-(2-amino-1,2-dioxoéthyle)-1-((1,1'-biphényl)-3-ylméthyl)-2-méthyl-1H-indol-4-yl)oxy)acétique, ainsi que son utilisation en tant que composé indolique présentant une biodisponibilité élevée et servant à inhiber la libération provoquée par l'intermédiaire de sPLA¿2? d'acides gras afin de traiter des états tels que le choc septique.

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