Morpholinopurine derivatives

Details Morpholinopurine derivatives Morpholinopurine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2740471

There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: (see formula 1) wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meanings as defined in the specification.

L'invention porte sur un nouveau composé qui peut inhiber la phosphatidylinositol 3-kinase (PI3K) et/ou une cible de mammifère de la rapamycine (mTOR) et a une activité anti-tumorale. L'invention porte spécifiquement sur un composé qui peut inhiber PI3K et/ou mTOR, a une activité anti-tumorale et est représenté par la formule (1) qui a divers substituants. [Dans la formule (1), R1, R2, R3, R4, Ra, Rb, Rc et X sont tels que définis dans la description].

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