Morpholinyl-urea derivatives for use of the treatment of...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61P 29/00 (2006.01) C07D 231/12 (2006.01) C07D 253/06 (2006.01) C07D 257/04 (2006.01) C07D 271/06 (2006.01) C07D 307/34 (2006.01) C07D 333/38 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2480106

Compounds of formula (I) wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5;R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6alkyl; R7 represents hydrogen or C1- 6alkyl; R8 represents hydrogen or C1-6alkyl;and salts and solvates thereof;are CCR3 antagonists and are thus indicated to be useful in therapy.

L'invention concerne des composés de formule générale (I) dans laquelle: R?1¿ représente hétéroaryle substitué ou non substitué; Y représente -(CR¿na?R¿nb?)¿n?-; R¿na? et R¿nb? représentent indépendamment hydrogène ou C¿1-6?alkyle; n est un nombre entier compris entre 0 et 5; R?2¿ représente aryle substitué ou non substitué ou hétéroaryle substitué ou non substitué; R?3¿ et R?4¿ représentent indépendamment hydrogène ou C¿1-6?alkyle; R?7¿ représente hydrogène ou C¿1-6?alkyle; R?8¿ représente hydrogène ou C¿1-6?alkyle; ainsi que des sels et des solvates de ceux-ci. Lesdits composés sont des antagonistes du récepteur CCR3 et sont ainsi destinés à être utilisés à des fins thérapeutiques.

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