Mouse model for psoriasis and psoriatic arthritis

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) C12N 5/071 (2010.01) C12N 15/90 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2552756

A mouse that is deficient for c-Jun and JunB in the epidermis or in which deletion of c-Jun and JunB can be specifically induced in the epidermis, and methods for obtaining such mice. The mice and keratinocytes derived therefrom are useful as an animal model for psoriasis and psoriatic arthritis.

La présente invention concerne une souris présentant une déficience en c-Jun et JunB dans l'épiderme ou dans laquelle la délétion de c-Jun et JunB peut être spécifiquement induite dans l'épiderme. Cette invention concerne également des procédés permettant d'obtenir de telles souris. Les souris et les kératinocytes provenant de ces souris sont utiles en tant que modèle animal pour le psoriasis et l'arthrite psoriasique.

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