Mouse monoclonal antibodies for post-exposure treatment of...

Details Mouse monoclonal antibodies for post-exposure treatment of... Mouse monoclonal antibodies for post-exposure treatment of...

A - Human Necessities

61

K

167/140

A61K 39/205 (2006.01) C07K 14/145 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2018508

MOUSE MONOCLONAL ANTIBODIES FOR POST-EXPOSURE TREATMENT OF RABIES ABSTRACT OF THE DISCLOSURE A monoclonal antibody cocktail is useful for post-exposure treat- ment of mammals for rabies and rabies-related viruses. The cocktail is immunoreactive with both glycoprotein and nucleoprotein epitopes of rabies virus and is cross-reactive with rabies-related virus Duvenhage and Mokola. The specific virus neutralizing activity is higher than human or equine anti-rabies hyper-immune sera presently recom- mended by the World Health Organization as the post-exposure therapy of choice.

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