Mouse-origin proteins forming domain or use thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07D 209/56 (2006.01) C07D 209/76 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2500883

It is intended to obtain proteins forming an SEA-like domain and being appropriate for structural analysis, analyze the structural data thereof and employ the results in drug discovery, etc. More specifically speaking, a protein comprising the amino acid sequence represented by SEQ ID NO:1 or a salt thereof, a protein having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:2 by deletion of 0 to 10 amino acids from the N-end and further deletion of 0 to 10 amino acids from the C-end and having from 120 to 139 amino acid residues or a salt thereof, a process for producing the same, polynucleotides encoding the same, antibodies against the above proteins, a screening method using the same, etc. are provided.

L'invention vise à obtenir des protéines formant un domaine du type SEA et appropriées pour l'analyse structurale, l'analyse de données structurale de celles-ci, et l'utilisation des résultats pour la découverte de médicaments, etc. Plus spécifiquement, l'invention concerne une protéine, ou un de ses sels, comprenant une séquence aminoacide représentée par SEQ ID NO : 1, une protéine ayant une séquence aminoacide dérivée de la séquence aminoacide représentée par SEQ ID NO : 2, par délétion de 0 à 10 aminoacides à partir de l'extrémité N, et autre délétion de 0 à 10 aminoacides à partir de l'extrémité C, et ayant de 120 à 139 restes aminoacides. L'invention concerne en outre un procédé de production de telles protéines, des polynucléotides codant pour celles-ci, des anticorps dirigés contre les protéines précitées, un procédé de criblage utilisant ces protéines, etc.

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