Mouse spermatogenesis genes, human male sterility-associated...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 7/04 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/52 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2476561

It is intended to provide mouse spermatogenesis genes constituting a mass of 89 genes cDNAs synthesized from mRNAs of which respectively have the base sequences represented by SEQ ID NOS:1 to 89; an Scot-t gene variant and a protamine-2 gene variant which are human homologs of genes belonging to the above gene mass and associated with human male sterility; a mass of mouse spermatogenesis genes and various molecular biological materials relating thereto; various molecular biological materials relating to male sterility- associated gene variants; and various test methods and diagnostic methods using the same.

La présente invention vise à fournir des gènes de spermatogenèse murine constituant une masse de 89 gènes d'ADNc synthétisés à partir d'ARNm qui présentent respectivement les séquences de base représentées par SEQ ID NOS : 1 à 89; un variant de gène Scot-t et un variant du gène protamine-2 qui sont les homologues humains des gènes appartenant à ladite masse de gènes et associés à la stérilité mâle humaine; une masse de gènes de spermatogenèse murine et divers matériaux biologiques moléculaires associés à ladite masse; divers matériaux biologiques associés aux variants des gènes associés à la stérilité mâle humaine ; et diverses méthodes d'essai et méthodes diagnostiques les mettant en oeuvre.

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