Mr methods of grading a tumor using an imaging medium that...

Details Mr methods of grading a tumor using an imaging medium that... Mr methods of grading a tumor using an imaging medium that...

A - Human Necessities

61

B

A61B 5/055 (2006.01) G01N 24/08 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2683023

The application relates to MR methods of grading a tumor using an imaging medium which comprises hyperpolarized 13C-pyruvate. In particular, it relates to a method of determining the grade of a tumor, said method comprises a) MR detecting a tumor in a subject using an imaging medium that comprises hyperpolarized13C-pyruvate wherein signals of 13C-pyruvate and its 13C-containing metabolites alanine, lactate and optionally bicarbonate are detected; b) using said signals and optionally the total carbon signal to generate a metabolic profile of the tumor; c) comparing the metabolic profile of the tumor generated in step b) to a known metabolic profile of a tumor of a certain grade; and d) determining the grade of the tumor based on the similarities and differences between said metabolic profile of the tumor and said known metabolic profile.

L'invention concerne des procédés d'imagerie par résonance magnétique de gradation d'une tumeur qui comprend du 13C-pyruvate hyperpolarisé. Elle concerne, plus particulièrement, un procédé de détermination du grade d'une tumeur, ce procédé consistant: a) à détecter par résonance magnétique une tumeur chez un sujet au moyen d'un support d'imagerie qui contient du 13C-pyruvate hyperpolarisé, les signaux du 13C-pyruvate et ses alanine, lactate et éventuellement bicarbonate de métabolites contenant du 13C étant détectés; b) à utiliser ces signaux et éventuellement le signal de carbone total pour produire un profil métabolique de la tumeur; c) à comparer le profil métabolique de la tumeur produit à l'étape b) à un profil métabolique connu de tumeur d'un certain grade; et d) à déterminer le grade de la tumeur sur la base des similitudes et des différences entre ce profil métabolique de la tumeur et le profil métabolique connu.

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