Mri contrast media recognizing microenvironmental changes

Details Mri contrast media recognizing microenvironmental changes Mri contrast media recognizing microenvironmental changes

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/12 (2006.01)

Patent

CA 2284205

Contrast media containing complexes of gadolinium (Gd)-base contrast media with polymers which undergo phase transition due to changes in pH value, light or temperature and thus become soluble in water; and a method of providing a contrast characterized by using these contrast media. Since the polymers responding to minor environmental changes are bonded to the Gd-base MRI contrast media, the performance of the contrast media can be exerted exclusively at the target sites, thus enabling on-off switching of the performance of MRI contrast media. Therefore, the obtained contrast media are highly specific ones by which the contrast is provided not at the sites where no contrast is needed but exclusively at the target tumors or specific sites, thus ensuring highly specific MRI diagnosis.

L'invention concerne des milieux de contraste contenant des complexes de milieux de contraste à base de gadolinium (Gd), et de polymères, qui subissent une transition de phase consécutive au changement de pH, de lumière ou de température et deviennent ainsi hydrosolubles. Elle porte aussi sur un procédé de production d'un contraste au moyen desdits milieux de contraste. Etant donné que les polymères réagissant aux modifications mineures de l'environnement sont liés aux milieux de contraste d'IRM à base de Gd, l'efficacité desdits milieux ne s'exerce que sur les sites cibles, ce qui permet l'activation ou la désactivation des milieux de contraste pour IRM. Les milieux de contraste ainsi obtenus sont hautement spécifique en ce que le contraste est assuré non pas au niveau des sites où aucun contraste n'est nécessaire, mais exclusivement au niveau des tumeurs cibles de sites spécifiques, ce qui permet d'assurer un diagnostic à IRM très spécifique.

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