Mrna ratios in urinary sediments and/or urine as a...

Details Mrna ratios in urinary sediments and/or urine as a... Mrna ratios in urinary sediments and/or urine as a...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2594125

Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut- off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.

L'invention concerne des procédés et des kits pour le pronostic du cancer de la prostate chez un sujet : (a) détermination du taux d'expression PCA3 et PSA dans un échantillon d'urine (b) corrélation entre la valeur du taux PCA3/PSA et le risque d'agressivité et de mortalité du cancer de la prostate chez le sujet. On décrit aussi des kits pour le pronostic du cancer de la prostate, et plus précisément un procédé de pronostic pour ce cancer dans un échantillon biologique de patient: évaluation de la quantité d'ARNm PCA3 spécifique à ce cancer et de la quantité de PSA dans l'échantillon; détermination d'un rapport entre la quantité d'ARNm PCA3 spécifique à ce cancer et la quantité de PSA ; comparaison entre ce rapport et au moins une valeur seuil préétablie, sachant qu'un rapport supérieur au seuil indique un risque plus élevé de mortalité du cancer de la prostate qu'un rapport inférieur au seuil.

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