Msp-3-like family of genes

Details Msp-3-like family of genes Msp-3-like family of genes

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2542924

The present invention relates to the protection against malaria. More particularly, the invention pertains to a family of genes encompassing the already known MSP-3 gene, and showing exceptional redundancy of exposed epitopes, hence suggesting that this family of genes plays an important part in the immunogenicity of the parasite. The characterization of this gene family enables the definition of immunogenic and vaccine compositions against P. falciparum. The invention also relates to an antigenic polypeptidic composition, comprising at least one MSP-3-b-like motif and at least one MSP- 3c/d-like motif.

L'invention concerne la protection contre le paludisme et, d'une manière plus spécifique, une nouvelle famille de gènes comprenant les gènes déjà connus du type MSP-3 et présentant une redondance exceptionnelle d'épitopes exposés, ce qui laisse supposer que cette famille de gènes joue un rôle important dans l'immunogénicité du parasite. La caractérisation de cette famille de gènes permet de définir une nouvelle composition immunogène et vaccinale contre P. falciparum. L'invention concerne également une composition polypeptidique antigénique, comprenant au moins un motif du type MSP-3-b et au moins un motif du type MSP-3-c/d.

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