Mtor kinase-associated proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2515515

The invention describes isolated mTor-associated proteins (~mTOR-APs~) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR- AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.

La présente invention a trait à des protéines isolées associées à la kinase mTOR ainsi qu'a des variants et fragments isolés de celles-ci et les acides nucléiques isolés codant pour lesdites protéines. L'invention a également trait à des vecteurs et des cellules hôtes contenant de l'acide nucléique codant pour un polypeptide de protéines associées à la kinase mTOR et des procédés pour la production d'un polypeptide de protéines associées à la kinase mTOR. L'invention a trait en outre à des procédés pour le criblage de composés modulateurs de l'activité de protéines associées à la kinase mTOR et des procédés pour le traitement ou la prévention d'un trouble sensible à la modulation des protéines associées à la kinase mTOR.

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