Mtp inhibiting aryl piperidines or piperazines substituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/04 (2006.01) A61P 19/00 (2006.01) C07D 233/54 (2006.01) C07D 249/08 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 413/12 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2558506

The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes (Formula (I)). The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper~triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.

La présente invention concerne des nouveaux composés de pipéridine d'aryle ou de pipérazine substitués par certains hétérocycles à 5 ramifications présentant une activité inhibitrice de la MTP et de la sécrétion de l'apoB ainsi qu'une activité concomitante hypolipidémiante. Cette invention concerne également des procédés permettant de préparer des tels composés, des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés en tant que médicament pour traiter l'hyperlipidémie, l'obésité, les diabètes de type II. (Formule (I)). Cette invention concerne également des procédés permettant de préparer ces composés, des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés en tant que médicaments pour traiter l'athérosclérose, la pancréatite, l'obésité, l'hypertriglycéridémie, l'hypercholestérolémie, l'hyperlipidémie, les diabètes et les diabètes de type II.

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