C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/52 (2006.01) A61K 31/216 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) C07C 231/02 (2006.01) C07C 231/16 (2006.01) C07C 233/57 (2006.01) C07C 233/78 (2006.01) C07C 235/54 (2006.01) C07C 235/60 (2006.01) C07D 207/14 (2006.01) C07D 223/12 (2006.01) C07D 265/30 (2006.01)
Patent
CA 2664143
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
La présente invention concerne de nouveaux dérivés acide tétrahydro-naphtalène-1-carboxylique ayant une activité d'inhibition de MTP/sécrétion d'apoB et une activité réduisant les lipides concomitants. L'invention concerne en outre des procédés de préparation de tels composés, des compositions pharmaceutiques comprenant lesdits composés ainsi que l'utilisation desdits composés en tant que médicament pour le traitement de l'athérosclérose, de la pancréatite, de l'obésité, de l'hypertriglycéridémie, de l'hypercholestérolémie, de l'hyperlipidémie, du diabète et du diabète de type II.
Backx Leo Jacobus Jozef
Busscher Guuske Frederike
Meerpoel Lieven
Ten Holte Peter
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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