Mts gene, mutations therein, and methods for diagnosing...

Details Mts gene, mutations therein, and methods for diagnosing... Mts gene, mutations therein, and methods for diagnosing...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2162147

The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition of melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Mutations somatiques du gène suppresseur de tumeurs multiples (MTS) dans les cancers humains, et leur utilisation dans le diagnostic et le pronostic du cancer humain. La présente invention concerne, en outre, des mutations de lignées germinales dans le gène MTS et leur utilisation dans le diagnostic de la prédisposition au mélanome, à la leucémie, à l'astrocytome, au glioblastome, au lymphome, au glione, à la maladie de Hodgkin, à la leucémie lymphocytaire chronique et aux cancers du pancréas, du sein, de la thyroïde, de l'ovaire, de l'utérus, du testicule, du rein, de l'estomac et du rectum. La présente invention concerne en outre le traitement de cancers humains qui présentent une mutation du gène MTS, dont la thérapie génique, le remplacement protéique et le mimétisme protéique. Enfin, la présente invention concerne la recherche de médicaments pour le traitement du cancer.

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