.mu.o-conopeptides and their use as local anesthetics

Details .mu.o-conopeptides and their use as local anesthetics .mu.o-conopeptides and their use as local anesthetics

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2376357

The present invention is directed to the new µO-conopeptides, their coding sequences and their propeptides and to the use of µO-conopeptides as a local anesthetic for treating pain. The µO-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operatively pain or via an intrathecal pump for severe chronic pain situations or for treatment of pain in epithelial tissue.

La présente invention concerne d'une part les nouveaux µO-conopeptides, leur séquences de codage, et leur propeptides, et d'autre part l'utilisation de ces µO-conopeptides comme anesthésiques locaux pour le traitement de la douleur. Ces µO-conopeptides, qui se distinguent par une action anesthésiante de longue durée, conviennent particulièrement pour l'anesthésie rachidienne, soit en administration aiguë contre la douleur post-opératoire, soit par pompe intrathécale pour les situations de douleur chronique sévère, ou pour le traitement de la douleur dans l'épithélium.

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