Muc-1 derived peptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2383737

Described are peptides and polypeptides derived from the MUC-1 polypeptide which are able to activate Cytotoxic T Lymphocyte (CTL) response, analogues of such peptides and polypeptides nucleotide sequences encoding such peptides and polypeptides and therapeutic uses thereof. Moreover, indications for selecting appropriate minimal antigenic MUC-1 polypeptides with reference to the HLA- type of the patient to be treated or tested are described.

L'invention concerne des peptides et des polypeptides dérivés du polypeptide MUC-1 pouvant activer la réponse des lymphocytes T cytotoxiques (CTL), des analogues de ces peptides et polypeptides, des séquences nucléotidiques codant pour ces peptides et polypeptides et leurs utilisations thérapeutiques. L'invention donne également des indications permettant de sélectionner les polypeptides MUC-1 antigéniques minimes appropriés en fonction du type de HLA du patient allant être soumis à un traitement ou à des tests.

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