Mucin-1 derived antigens and their use in immunotherapy

Details Mucin-1 derived antigens and their use in immunotherapy Mucin-1 derived antigens and their use in immunotherapy

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2399026

Peptides and polypeptides capable of eliciting the immune response are disclosed which comprise an amino acid sequence substantially corresponding to that of an epitope of the non-VNTR, non-leader region of mucin. The peptides or polypeptides are useful themselves, or in the form of fusion proteins or conjugate compounds with carbohydrate polymers, in the prevention or treatment of disease states, particularly carcinomas such as adenocarcinomas. DNA vaccines and uses of the peptides and polypeptides for pulsing dentritic cells for in vivo transfer are also disclosed.

L'invention concerne des peptides et des polypeptides qui peuvent éliciter la réponse immunitaire et qui renferment une séquence d'acides aminés correspondant pratiquement à celle d'un épitope de la région de séquence non guide, non VNTR de la mucine. Les peptides ou les polypeptides sont utilisés sous leur forme première ou sous forme de protéines hybrides ou de composés conjugués avec des polymères d'hydrates de carbone, dans la prévention ou le traitement de maladies, notamment de carcinomes tels que l'adénocarcinomes. Cette invention concerne également des vaccins d'ADN et des utilisations des peptides et polypeptides permettant de transmettre des impulsions à des cellules dendritiques en vue d'un transfert in vivo.

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