Mucin-1 specific binding members and methods of use thereof

Details Mucin-1 specific binding members and methods of use thereof Mucin-1 specific binding members and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2403998

MUC1-specific binding members for cancer-associated MUC1 protein comprise a MUC1 binding domain, or portion thereof, for binding to an epitope of the protein core of MUC1. The MUC1-specific binding members comprise various antibody molecules and fragments thereof, including Fab antibodies; scFv antibodies; double scFv antibodies; diabodies; recombinant, full-length immunoglobulins; and immunocytokine fusion proteins; that are used in methods of diagnosing and treating cancer in various tissues, including breast, ovary, bladder, and lung, and in methods of purifying or isolating MUC1 protein. Polynucleotide molecules encoding MUC1-specific binding members, or portions thereof, are also described.

Ces éléments de liaison spécifiques de MUC1 à des protéines de MUC1 associées à un cancer comportent un domaine de liaison à MCU1, ou à un fragment de celle-ci, aux fins de la fixation à un épitope du noyau de la protéine de MUC1. Ces éléments de liaison spécifiques de MUC1 comportent diverses molécules d'anticorps et leurs fragments, dont des anticorps Fab, des anticorps scFv, des anticorps scFv doubles, des dia-anticorps, des immunoglobulines de recombinaison pleine longueur et des protéines hybrides d'immunocytokine. On utilise ces éléments pour le diagnostic et le traitement des cancers de divers tissus, notamment les cancers du sein, des ovaires et du poumon, ainsi que pour purifier ou isoler la protéine de MUC1. Cette invention porte également sur des molécules polynucléotidiques codant ces éléments de liaison spécifiques de MUC1 ou leurs fragments.

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