Mucin containing ophthalmic preparations

Details Mucin containing ophthalmic preparations Mucin containing ophthalmic preparations

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 9/00 (2006.01) A61K 38/14 (2006.01) A61P 27/04 (2006.01)

Patent

CA 2362498

The present invention discloses the ophthalmic applications of mucin derived from mammalian milk or milk byproducts. This mucin has been found to be a MUC1 type mucin similar to the transmembrane mucin expressed on the surface of the human eye. The mucin-containing preparations described in this invention can be in the form of an aqueous formulation to be instilled into the eye, or in which the pre-soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of tear film and ocular surface disorders associated with the signs and symptoms of dry eye. Furthermore, mucin-based formulations are also effective for the relief of symptoms of eye irritation, such as those caused by environmental conditions or by contact lens wear.

La présente invention concerne des applications ophtalmiques de mucine dérivée de lait ou de produits dérivés du lait de mammaliens. On a découvert que cette mucine est une mucine du type MUC1 similaire à la mucine transmembranaire exprimée à la surface de l'oeil humain. Les préparations contenant de la mucine selon l'invention peuvent être sous forme de formulation aqueuse destinée à être instillée dans l'oeil, ou dans laquelle on trempe au préalable ou on conserve un objet destiné à être introduit dans l'oeil tel qu'une lentille de contact, une pommade ou un dispositif solide destiné à être introduit dans le sac conjonctival. Les préparations selon l'invention s'utilisent dans le traitement de troubles du film lacrymal et de la surface oculaire associés aux signes et aux symptômes de la kératoconjonctivite sèche. En outre, les formulations à base de mucine soulagent efficacement les symptômes d'irritation des yeux, tels que ceux provoqués par les conditions ambiantes ou le port de lentilles de contact.

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