Mucin-mediated immunomodulation

Details Mucin-mediated immunomodulation Mucin-mediated immunomodulation

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2269349

Disclosed is a method of decreasing or preventing the deleterious effects of cytotoxic T lymphocytes that involves identifying an animal having a non-tumor cell at risk of attack by the animal's cytotoxic T lymphocytes, and providing to the cell a molecule having at least one tandem repeat segment of a mucin. Also disclosed is a method of augmenting the immune response against a tumor cell expressing a mucin, using a composition that binds to the tandem repeat segment of the mucin and blocks the CTL-inhibiting effects of the mucin.

L'invention concerne un procédé destiné à réduire ou à prévenir les effets toxiques des lymphocytes T cytotoxiques, qui consiste à identifier un animal possédant une cellule non tumorale exposée à une attaque par les lymphocytes T cytotoxiques de l'animal, et à fournir ladite cellule une molécule présentant au moins une séquence répétée en tandem d'une mucine. L'invention concerne également un procédé destiné à augmenter la réponse immunitaire contre une cellule tumorale exprimant une mucine, à l'aide d'une composition qui se lie à la séquence répétée en tandem de la mucine et qui bloque les effets inhibiteurs des CTL de la mucine.

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