Mucosal immunogenic substances comprising a polyinosinic...

Details Mucosal immunogenic substances comprising a polyinosinic... Mucosal immunogenic substances comprising a polyinosinic...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2632418

The present invention provides a polynucleotide adjuvant (PICKCa) composition and methods of use in eliciting an immune response, in particular a mucosal immune response. The polynucleotide adjuvant comprises of a polyriboinosinic- polyribocytidylic acid (PIC), at least one antibiotic and at least one positive ion. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with other immunogenic compositions such as an antigen (e.g., as in a vaccine). The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response, in particular a mucosal immune response to an antigenic compound.

La présente invention concerne une composition d'adjuvant polynucléotidique (PICKCa) et des procédés d'utilisation de celle-ci pour provoquer une réponse immune, en particulier une réponse immune des muqueuses. L'adjuvant polynucléotidique comprend un acide polyriboinosinique-polyribocytidylique (PIC), au moins un antibiotique et au moins un ion positif. La présente invention concerne également une composition immunogénique contenant la composition d'adjuvant polynucléotidique et d'autres compositions immunogéniques, par exemple un antigène (par exemple, dans un vaccin). La présente invention concerne également des procédés d'utilisation desdites compositions d'adjuvant, en particulier pour provoquer une réponse immune, et plus particulièrement une réponse immune des muqueuses à un composé antigénique.

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