A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/04 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2322175
Mucosal, particularly oral, microparticle conjugate vaccines against certain pathogenic microorganisms, especially intracellular pathogenic microorganisms, are disclosed. An immunizing component of such a vaccine comprises protection- generating antigens derived from a certain pathogenic microorganism, such as Mycobacterium tuberculosis or Salmonella enteritidis, conjugated, possibly via a linker, to biodegradable microparticles, particularly starch microparticles, such as cross-linked starch microparticles, e.g. polyacryl starch microparticles. Further, a method of inducing protective immunity against a certain pathogenic microorganism in a mammal, and the use of protection- generating antigens derived from a certain pathogenic microorganism conjugated, possibly via a linker, to biodegradable microparticles for the production of a mucosal microparticle conjugate vaccine, are described.
L'invention concerne des vaccins conjugués à des microparticules d'administration mucosale, notamment orale, contre certains micro-organismes pathogènes, notamment des micro-organismes phathogènes intracellulaires. Un composant immunisant d'un tel vaccin comprend des antigènes générateurs de protection dérivés d'un certain micro-organisme pathogène, tel que Mycobacterium tuberculosis ou Salmonella enteritidis, conjugué, éventuellement via un lieur, à des microparticules biodégradables, en particulier des microparticules d'amidon, telles que des microparticules d'amidon réticulées, p.ex. des microparticules d'amidon polyacryle. L'invention concerne également un procédé d'introduction d'une immunité de protection contre un certain micro-organisme pathogène dans l'organisme d'un mammifère, et l'utilisation d'antigènes générateurs de protection dérivés d'un certain micro-organisme pathogène conjugué, éventuellement via un lieur, à des particules biodégradables pour la production d'un vaccin conjugué à microparticules des muqueuses.
Degling Wikingsson Lena
Sjoholm Ingvar
Degling Wikingsson Lena
Innoventus Project Ab
Marks & Clerk
Sjoholm Ingvar
LandOfFree
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