Muller stem cells

Details Muller stem cells Muller stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/0793 (2010.01) A61K 35/44 (2006.01) A61L 27/38 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2547233

A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Miller cells into a progenitor phenotype.

L'invention concerne une méthode de production de cellules rétiniennes utiles en thérapie par greffe. La méthode consiste à: i) obtenir une ou plusieurs cellules de Müller adultes d'un mammifère; et ii) cultiver les cellules en présence d'une porine extracellulaire et d'un facteur de croissance, afin d'induire une différenciation des cellules de Müller et de produire un phénotype progéniteur.

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