A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61P 31/16 (2006.01)
Patent
CA 2366316
A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least three different antigens of Haemophilus influenzae, two of which are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus influenzae comprise the adhesin components while the other antigen is a non- proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The Haemophilus vaccine may be combined with DTP component vaccines, which may contain inactivated poliovirus, including type 1, type 2 and/or type 3, and/or a conjugate of a capsular polysaccharide of Haemophilus influenzae and tetanus or diphtheria toxoid, including PRP-T, to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
L'invention concerne une composition immunogène à multiples composants assurant la protection d'un hôte immunisé contre l'infection causée par l'Haemophilus influenzae. Cette composition renferme au moins trois antigènes différents de l'Haemophilus influenzae, dont deux sont des adhésines. Des protéines à masse moléculaire élevée (HMW) et des protéines de l'adhésine d'Haemophilus influenzae (Hia) d'Haemophilus influenzae de type non déterminable renferment les composants d'adhésine tandis que l'autre antigène est un analogue non protéolytique de protéine Hin47. Les composants n'affectent pas tous l'immunogénécité des autres. Le vaccin contre l'Haemophilus peut être combiné à des vaccins à composants DTP susceptibles de contenir un poliovirus inactivé, y compris le type 1, type 2 et/ou type 3, et/ou un conjugué d'un polysaccharide capsulaire de l'Haemophilus influenzae et l'anatoxine tétanique ou diphtérique, y compris PRP-T, de manière à offrir un vaccin à composants multi-valents sans pour autant affecter les propriétés immunogènes des autres antigènes.
Klein Michel H.
Loosmore Sheena M.
Yang Yan-Ping
Aventis Pasteur Limited
Yacoob Reza K.
LandOfFree
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