A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2691777
Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.
La présente invention concerne des compositions et des procédés pour modifier des substances actives sur le plan biologique afin d'obtenir une délivrance sur plusieurs jours de ces substances, particulièrement par l'intermédiaire d'une administration orale ou parentérale. Les compositions renferment la substance active sur le plan biologique conjuguée à un support présentant une demi-vie d'une durée appropriée, généralement de plus d'un jour, où le conjugué contient éventuellement un espaceur liant le support à la substance active sur le plan biologique. L'invention concerne également des formulations pharmaceutiques des conjugués ainsi que des procédés pour prolonger la délivrance d'une dose unique d'une substance active sur le plan biologique pendant plus d'un jour.
Mccarthy Tetrault Llp
Samos Pharmaceuticals Llc
LandOfFree
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