G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 24/00 (2006.01) G01N 30/02 (2006.01) G01N 30/46 (2006.01) G01N 33/00 (2006.01) G01N 33/566 (2006.01) G01N 30/88 (2006.01)
Patent
CA 2494998
The present invention relates to multidimensional chromatography systems for proteomics and methods for identifying lower-abundance proteins in body fluids. Abundant proteins(s) is first removed by affinity chromatography utilizing affinity chromatographic column functionalized with ligand capable of selectively binding the abundant protein in the sample. Multidimensional chromatographic techniques are applied to the eluent with a reduced content of the abundant protein followed by mass spectrometric analysis.
L'invention concerne de manière générale des procédés et des compositions servant à identifier des biomolécules présentes dans un échantillon biologique. Plus spécifiquement, l'invention concerne des procédés de spectrométrie de masse et des compositions servant à identifier des protéines présentes dans un fluide corporel.
Baussant Thierry
Boehm Guenter
Heller Manfred
Kussmann Martin
Menin Laure
Baussant Thierry
Boehm Guenter
Geneprot Inc.
Gowling Lafleur Henderson Llp
Heller Manfred
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