Multi-dose concentrate esmolol with benzyl alcohol

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01)

Patent

CA 2686566

Disclosed are concentrate esmolol injection essentially free from other related esters of esmolol and diluted esmolol compositions. The concentrate esmolol formulation includes from about 25-1000 mg/ml of esmolol and about 1-25 % w/v of benzyl alcohol and the combination thereof. The compositions can also be used as multi-dose compositions. The present invention also discloses diluted, ready-to-use compositions of esmolol prepared by dilution of the present invention concentrates. Also disclosed are methods of making and using the ready-to-use compositions of the present invention.

L'invention concerne une injection d'esmolol concentré essentiellement dépourvue d'autres esters d'esmolol apparentés, et des compositions d'esmolol dilué. La formulation d'esmolol concentré comprend environ 25-1000 mg/ml d'esmolol et environ 1-25 % M/V d'alcool benzylique, et la combinaison de ceux-ci. Ces compositions peuvent aussi être utilisées comme compositions multidose. L'invention concerne aussi des compositions d'esmolol dilué prêtes à l'emploi, préparées par la dilution des concentrés de l'invention. L'invention concerne aussi des procédés de fabrication et d'utilisation des compositions prêtes à l'emploi de l'invention.

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