Multi-functional small molecules as anti-proliferative agents

Details Multi-functional small molecules as anti-proliferative agents Multi-functional small molecules as anti-proliferative agents

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2662937

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.

L'invention concerne des compositions, des procédés, et des applications d'une approche nouvelle permettant d'effectuer une inhibition sélective de plusieurs cibles cellulaires ou moléculaires à l'aide d'une seule petite molécule. En particulier, l'invention concerne de petites molécules multifonctionnelles présentant une fonction d'inhibition d'histone désacétylases (HDAC) et une autre fonction permettant d'inhiber une voie cellulaire ou moléculaire différente impliquée dans une prolifération cellulaire aberrante, dans une différenciation cellulaire aberrante ou dans une survie cellulaire aberrante.

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