Multi-leu peptides and analogues thereof as selective pace4...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/11 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2727574

Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.

L'invention porte sur des inhibiteurs de PACE4, sur des compositions comprenant des inhibiteurs de PACE4 et sur leurs utilisations pour l'abaissement de l'activité de PACE4, la réduction de la prolifération cellulaire, la réduction de la croissance tumorale, la réduction de la formation de métastases, la prévention et/ou le traitement d'un cancer. L'invention porte également sur des procédés pour l'abaissement de l'activité de PACE4, la réduction de la prolifération d'une cellule, la réduction de la croissance tumorale et/ou le traitement et la prévention d'un cancer. L'invention porte en outre sur des procédés pour le criblage d'inhibiteurs de PACE4 et d'inhibiteurs de la prolifération cellulaire.

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